Medscape - Schizophrenia, bipolar disorder-specific dosing for Seroquel, Seroquel XR (quetiapine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy &. Elderly patients should be started on SEROQUEL 50 mg/day and the dose can be increased in increments of 50 mg/day depending on the clinical response and tolerability of the individual patient. This article describes the dosage of Seroquel, as well as its strengths and how to take it. » Learn more about Seroquel, including its uses and side effects. At very low doses, quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α 1 -adrenergic blocker. When the dose is increased, quetiapine activates the adrenergic system and binds strongly to serotonin receptors and autoreceptors. Detailed Quetiapine dosage information for adults, the elderly and children. Includes dosages for Depression, Bipolar Disorder and Schizophrenia; plus renal, liver and dialysis adjustments. This article describes the dosages of Seroquel, as well as its strengths and how to take it. To learn more about Seroquel, see this in-depth article. Note: This article focuses on Seroquel. Detailed dosage guidelines and administration information for Seroquel (quetiapine fumarate). Includes dose adjustments, warnings and precautions. Quetiapine tablets may be taken with or without food on a full or empty stomach. However, if your doctor tells you to take it a certain way, take it as directed. For most patients, the therapeutic dose range of 300-800 mg/day provides optimal balance between efficacy and tolerability, with doses above this range reserved for treatment-resistant cases. The recommended adult dose of Seroquel is 150 mg to 750 mg per day for schizophrenia. For Seroquel XR, the recommended dose is 400 mg to 800 mg per day for schizophrenia.